I'm very pleased with these pain relief patches for my arthritic knee problem. Was desperately looking for any non-invasive solution other than taking more over the counter pain meds, and one that also contained natural ingredients Decided to try them based on positive reviews. Turned out to be an excellent solution! I can walk, climb stairs practically all day with so much more ease, and comfort that I almost forget I'm even wearing the patch until the end of the day when I'm about to shower! They are the answer to my prayers, & I highly recommend them.